Integrated device for optical stimulation and spatiotemporal electrical recording of neural activity in light-sensitized brain tissue.

@article{Zhang2009IntegratedDF,
  title={Integrated device for optical stimulation and spatiotemporal electrical recording of neural activity in light-sensitized brain tissue.},
  author={Jiayi Zhang and Farah Laiwalla and Jennifer A. Kim and Hayato Urabe and Rick Van Wagenen and Yoon-Kyu Song and Barry W. Connors and Feng Zhang and Karl Deisseroth and Arto V. Nurmikko},
  journal={Journal of neural engineering},
  year={2009},
  volume={6 5},
  pages={055007}
}
Neural stimulation with high spatial and temporal precision is desirable both for studying the real-time dynamics of neural networks and for prospective clinical treatment of neurological diseases. Optical stimulation of genetically targeted neurons expressing the light sensitive channel protein Channelrhodopsin (ChR2) has recently been reported as a means for millisecond temporal control of neuronal spiking activities with cell-type selectivity. This offers the prospect of enabling local… CONTINUE READING