Integrated behavioral <ce:italic>z</ce:italic>-scoring increases the sensitivity and reliability of behavioral phenotyping in mice: Relevance to emotionality and sex

@article{Guilloux2011IntegratedB,
  title={Integrated behavioral <ce:italic>z</ce:italic>-scoring increases the sensitivity and reliability of behavioral phenotyping in mice: Relevance to emotionality and sex},
  author={Jean-Philippe Guilloux and Marianne L Seney and Nicole E Edgar and Etienne Sibille},
  journal={Journal of Neuroscience Methods},
  year={2011},
  volume={197},
  pages={21-31}
}
Defining anxiety- and depressive-like states in mice (emotionality) is best characterized by the use of complementary tests, leading sometimes to puzzling discrepancies and lack of correlation between similar paradigms. To address this issue, we hypothesized that integrating measures along the same behavioral dimensions in different tests would reduce the intrinsic variability of single tests and provide a robust characterization of the underlying "emotionality" of individual mouse, similarly… CONTINUE READING
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