Integrated analysis reveals critical genomic regions in prostate tumor microenvironment associated with clinicopathologic phenotypes.

@article{Ashida2012IntegratedAR,
  title={Integrated analysis reveals critical genomic regions in prostate tumor microenvironment associated with clinicopathologic phenotypes.},
  author={Shingo Ashida and Mohammed Orloff and Gurkan Bebek and Li Zhang and Pan Zheng and Donna M. Peehl and Charis Eng},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2012},
  volume={18 6},
  pages={1578-87}
}
PURPOSE Recent studies suggest that tumor microenvironment (stroma) is important in carcinogenesis and progression. We sought to integrate global genomic structural and expressional alterations in prostate cancer epithelium and stroma and their association with clinicopathologic features. EXPERIMENTAL DESIGN We conducted a genome-wide LOH/allelic imbalance (AI) scan of DNA from epithelium and stroma of 116 prostate cancers. LOH/AI hot or cold spots were defined as the markers with… CONTINUE READING
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