Integrated analysis of somatic mutations and immune microenvironment in malignant pleural mesothelioma.

@article{Kiyotani2017IntegratedAO,
  title={Integrated analysis of somatic mutations and immune microenvironment in malignant pleural mesothelioma.},
  author={Kazuma Kiyotani and Jae-Hyun Park and Hiroyuki Inoue and Aliya N. Husain and Sope Olugbile and Makda Zewde and Yusuke Nakamura and Wickii T. Vigneswaran},
  journal={Oncoimmunology},
  year={2017},
  volume={6 2},
  pages={
          e1278330
        }
}
To investigate the link between the genomic landscape of cancer cells and immune microenvironment in tumor tissues, we characterized somatic mutations and tumor-infiltrating lymphocytes (TILs) in malignant pleural mesothelioma (MPM), including mutation/neoantigen load, spatial heterogeneity of somatic mutations of cancer cells and TILs (T-cell receptor β (TCRβ) repertoire), and expression profiles of immune-related genes using specimens of three different tumor sites (anterior, posterior, and… CONTINUE READING
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