Integrated analysis of genome-wide methylation and gene expression shows epigenetic regulation of CYP11B2 in aldosteronomas.

@article{Howard2014IntegratedAO,
  title={Integrated analysis of genome-wide methylation and gene expression shows epigenetic regulation of CYP11B2 in aldosteronomas.},
  author={Brandi Howard and Yonghong Wang and Paraskevi Xekouki and F{\'a}bio Rueda Faucz and Meenu Jain and Lisa Zhang and Paul G Meltzer and Constantine A Stratakis and Electron Kebebew},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2014},
  volume={99 3},
  pages={E536-43}
}
CONTEXT Differential methylation of CpG regions is the best-defined mechanism of epigenetic regulation of gene expression. OBJECTIVE Our objective was to determine whether any changes in methylation are associated with aldosteronomas. METHODS We performed integrated genome-wide methylation and gene expression profiling in aldosteronomas (n = 25) as compared with normal adrenal cortical tissue (n = 10) and nonfunctioning adrenocortical tumors (n = 13). To determine the effect of… CONTINUE READING
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