Integrated Regional Cardiac Hemodynamic Imaging and RNA Sequencing Reveal Corresponding Heterogeneity of Ventricular Wall Shear Stress and Endocardial Transcriptome.

@article{McCormick2016IntegratedRC,
  title={Integrated Regional Cardiac Hemodynamic Imaging and RNA Sequencing Reveal Corresponding Heterogeneity of Ventricular Wall Shear Stress and Endocardial Transcriptome.},
  author={Margaret E. McCormick and Elisabetta Manduchi and Walter R. T. Witschey and Robert C. Gorman and Joseph H. Gorman and Yi-Zhou Jiang and Christian J. Stoeckert and Alex J Barker and Michael Markl and Peter Francis Davies},
  journal={Journal of the American Heart Association},
  year={2016},
  volume={5 4},
  pages={e003170}
}
BACKGROUND Unlike arteries, in which regionally distinct hemodynamics are associated with phenotypic heterogeneity, the relationships between endocardial endothelial cell phenotype and intraventricular flow remain largely unexplored. We investigated regional differences in left ventricular wall shear stress and their association with endocardial endothelial… CONTINUE READING