Integrated Multidimensional Analysis Is Required for Accurate Prognostic Biomarkers in Colorectal Cancer

@inproceedings{Mariani2014IntegratedMA,
  title={Integrated Multidimensional Analysis Is Required for Accurate Prognostic Biomarkers in Colorectal Cancer},
  author={Marisa Mariani and Shiquan He and Mark Mchugh and Mirko Andreoli and Deep Pandya and Steven C Sieber and Zheyang Wu and Paul N. Fiedler and Shohreh Shahabi and Cristiano Ferlini},
  booktitle={PloS one},
  year={2014}
}
CRC cancer is one of the deadliest diseases in Western countries. In order to develop prognostic biomarkers for CRC (colorectal cancer) aggressiveness, we analyzed retrospectively 267 CRC patients via a novel, multidimensional biomarker platform. Using nanofluidic technology for qPCR analysis and quantitative fluorescent immunohistochemistry for protein analysis, we assessed 33 microRNAs, 124 mRNAs and 9 protein antigens. Analysis was conducted in each single dimension (microRNA, gene or… CONTINUE READING
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