Integrated Morphoelectric and Transcriptomic Classification of Cortical GABAergic Cells

@article{Gouwens2020IntegratedMA,
  title={Integrated Morphoelectric and Transcriptomic Classification of Cortical GABAergic Cells},
  author={Nathan W. Gouwens and Staci A. Sorensen and Fahimeh Baftizadeh and Agata Budzillo and Brian R. Lee and Tim Jarsky and Lauren Alfiler and Katherine Baker and Eliza Barkan and Kyla Berry and Darren Bertagnolli and Kris Bickley and Jasmine Bomben and Thomas Braun and Krissy Brouner and Tamara Casper and Kirsten Crichton and Tanya L. Daigle and Rachel Dalley and Rebecca de Frates and Nick Dee and Tsega Desta and Samuel Dingman Lee and Nadezhda Dotson and Tom Egdorf and Lauren Ellingwood and Rachel Enstrom and Luke Esposito and Colin Farrell and David Feng and Olivia Fong and Rohan Gala and Clare Gamlin and Amanda Gary and Alexandra Glandon and Jeff Goldy and Melissa Gorham and Lucas T. Graybuck and Hong Gu and Kristen Hadley and Michael J. Hawrylycz and Alex M. Henry and DiJon Hill and Madie Hupp and Sara Kebede and Tae Kyung Kim and Lisa Kim and Matthew Kroll and Changkyu Lee and Katherine E. Link and Matthew Mallory and Rusty Mann and Michelle Maxwell and Medea McGraw and Delissa McMillen and Alice Mukora and Lindsay Ng and Lydia Ng and Kiet Ngo and Philip R. Nicovich and Aaron Oldre and Daniel Park and Hanchuan Peng and Osnat Penn and Thanh Pham and Alice Pom and Zoran B. Popovi{\'c} and Lydia Potekhina and Ram Rajanbabu and Shea Ransford and David Reid and Christine Rimorin and Miranda Robertson and Kara Ronellenfitch and Augustin Ruiz and David Sandman and Kimberly A. Smith and Josef Sulc and Susan M. Sunkin and Aaron Szafer and Michael Tieu and Amy Torkelson and Jessica Trinh and Herman Tung and Wayne Wakeman and Katelyn Ward and Grace Williams and Zhi Zhou and Jonathan T. Ting and Anton Arkhipov and Uygar S{\"u}mb{\"u}l and Ed S. Lein and Christof Koch and Zizhen Yao and Bosiljka Tasic and Jim Berg and Gabe J. Murphy and Hongkui Zeng},
  journal={Cell},
  year={2020},
  volume={183},
  pages={935-953.e19}
}
Neurons are frequently classified into distinct types on the basis of structural, physiological, or genetic attributes. To better constrain the definition of neuronal cell types, we characterized the transcriptomes and intrinsic physiological properties of over 4,200 mouse visual cortical GABAergic interneurons and reconstructed the local morphologies of 517 of those neurons. We find that most transcriptomic types (t-types) occupy specific laminar positions within visual cortex, and, for most… Expand
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