Integrated Molecular and Clinical Analysis of AKT Activation in Metastatic Melanoma.

@article{Davies2009IntegratedMA,
  title={Integrated Molecular and Clinical Analysis of AKT Activation in Metastatic Melanoma.},
  author={Michael A. Davies and Katherine Stemke-Hale and Eva Lin and Carmen Tellez and Wanleng Deng and Y. N. Vashisht Gopal and Scott E. Woodman and Tiffany C Calderone and Zhenlin Ju and Alexander J Lazar and Victor G Prieto and Kenneth D. Aldape and Gordon B. Mills and Jeffrey E Gershenwald},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2009},
  volume={15 24},
  pages={7538-7546}
}
PURPOSE: Activation of the phosphoinositide 3-kinase (PI3K)-AKT pathway has been implicated in melanoma based primarily on the prevalence of mutations in PTEN and NRAS. To improve our understanding of the regulation and clinical significance of the PI3K-AKT pathway in melanoma, we quantitatively measured the levels of phosphorylated AKT, its substrate GSK3alpha/beta, and its negative regulator PTEN in clinical metastases. Results were compared with mutational status, clinical outcomes, and… CONTINUE READING
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