Integrated Genotypic Analysis of Hedgehog-Related Genes Identifies Subgroups of Keratocystic Odontogenic Tumor with Distinct Clinicopathological Features

@inproceedings{Shimada2013IntegratedGA,
  title={Integrated Genotypic Analysis of Hedgehog-Related Genes Identifies Subgroups of Keratocystic Odontogenic Tumor with Distinct Clinicopathological Features},
  author={Yasuyuki Shimada and Ken-ichi Katsube and Yuji Kabasawa and Kei-ichi Morita and Ken Omura and Akira Yamaguchi and Kei Sakamoto},
  booktitle={PloS one},
  year={2013}
}
Keratocystic odontogenic tumor (KCOT) arises as part of Gorlin syndrome (GS) or as a sporadic lesion. Gene mutations and loss of heterozygosity (LOH) of the hedgehog receptor PTCH1 plays an essential role in the pathogenesis of KCOT. However, some KCOT cases lack evidence for gene alteration of PTCH1, suggesting that other genes in the hedgehog pathway may… CONTINUE READING