Integrated Expression Profiling and Genome-Wide Analysis of ChREBP Targets Reveals the Dual Role for ChREBP in Glucose-Regulated Gene Expression

@inproceedings{Jeong2011IntegratedEP,
  title={Integrated Expression Profiling and Genome-Wide Analysis of ChREBP Targets Reveals the Dual Role for ChREBP in Glucose-Regulated Gene Expression},
  author={Yun-Seung Jeong and Deokhoon Kim and Yong Seok Lee and Ha-Jung Kim and Jung-Youn Han and Seung Soon Im and Hansook Kim Chong and Je-Keun Kwon and Yun-Ho Cho and Woo Kyung Kim and Timothy F. Osborne and Jay D. Horton and Hee-Sook Jun and Yong-Ho Ahn and Sung-Min Ahn and Ji Young Cha},
  booktitle={PloS one},
  year={2011}
}
The carbohydrate response element binding protein (ChREBP), a basic helix-loop-helix/leucine zipper transcription factor, plays a critical role in the control of lipogenesis in the liver. To identify the direct targets of ChREBP on a genome-wide scale and provide more insight into the mechanism by which ChREBP regulates glucose-responsive gene expression, we performed chromatin immunoprecipitation-sequencing and gene expression analysis. We identified 1153 ChREBP binding sites and 783 target… CONTINUE READING