Integrated DNA methylation and copy-number profiling identifies three clinically and biologically relevant groups of anaplastic glioma

@inproceedings{Benedikt2017IntegratedDM,
  title={Integrated DNA methylation and copy-number profiling identifies three clinically and biologically relevant groups of anaplastic glioma},
  author={Benedikt and Wiestler and David and Capper and Mart{\'i}n and Sill and TW and Louise Jones and Volker Hovestadt and Dominik Sturm and Christian Koelsche and Anna Bertoni and Leonille Schweizer and Andrey Korshunov and Elisa K. Wei\ss and Maximilian Georg Schliesser and Alexander Radbruch and Christel C. Herold-Mende and Patrick Roth and Andreas Unterberg and Christian Hartmann and Torsten Pietsch and Guido and Reifenberger and H C K Peter and Lichter and Bernhard and Radlwimmer and Michael Platten and Stefan M. Pfister and Andreas von Deimling and Michael Weller and Wolfgang Wick},
  year={2017}
}
The outcome of patients with anaplastic gliomas varies considerably. Whether a molecular classification of anaplastic gliomas based on large-scale genomic or epigenomic analyses is superior to histopathology for reflecting distinct biological groups, predicting outcomes and guiding therapy decisions has yet to be determined. Epigenome-wide DNA methylation… CONTINUE READING