Integrase inhibitor reversal dynamics indicate unintegrated HIV-1 dna initiate de novo integration

  title={Integrase inhibitor reversal dynamics indicate unintegrated HIV-1 dna initiate de novo integration},
  author={Sylvain Thierry and Soundasse Munir and Elo{\"i}se Thierry and Fr{\'e}d{\'e}ric Subra and Herv{\'e} Leh and Alessia Zamborlini and Dyana Saenz and David N Levy and Paul Lesbats and Ali Sa{\"i}b and Vincent Parissi and Eric M. Poeschla and Eric Deprez and Olivier Delelis},
Genomic integration, an obligate step in the HIV-1 replication cycle, is blocked by the integrase inhibitor raltegravir. A consequence is an excess of unintegrated viral DNA genomes, which undergo intramolecular ligation and accumulate as 2-LTR circles. These circularized genomes are also reliably observed in vivo in the absence of antiviral therapy and they persist in non-dividing cells. However, they have long been considered as dead-end products that are not precursors to integration and… CONTINUE READING
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