Integral rein control in physiology.

  title={Integral rein control in physiology.},
  author={Peter T. Saunders and Johan H Koeslag and J A Wessels},
  journal={Journal of theoretical biology},
  volume={194 2},
We propose that blood glucose is regulated by a principle which we call integral rein control, in which under most conditions both glucagon and insulin are produced and control is achieved by altering the balance between the two. Like other integral control systems, the mechanism achieves zero steady-state error, which explains how the blood glucose level can remain very nearly constant over a wide range of input and demand. In addition, the use of two hormones makes the system stable against… CONTINUE READING
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  • J. H. S11-S20. Koeslag, P. T. Saunders, J. A. Wessels
  • J. Endocrinology 154,
  • 1997
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  • A. J. Watson, J. E. Lovelock
  • Tellus
  • 1983
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  • F. J. Seif
  • nat. Acad. Sci. USA
  • 1979
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