Integral rein control in physiology.

@article{Saunders1998IntegralRC,
  title={Integral rein control in physiology.},
  author={Peter T. Saunders and Johan H Koeslag and J A Wessels},
  journal={Journal of theoretical biology},
  year={1998},
  volume={194 2},
  pages={163-73}
}
We propose that blood glucose is regulated by a principle which we call integral rein control, in which under most conditions both glucagon and insulin are produced and control is achieved by altering the balance between the two. Like other integral control systems, the mechanism achieves zero steady-state error, which explains how the blood glucose level can remain very nearly constant over a wide range of input and demand. In addition, the use of two hormones makes the system stable against… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 31 extracted citations

References

Publications referenced by this paper.
Showing 1-9 of 9 references

Glucose homeostasis with infinite gain: An application of the Daisyworld parable

  • J. H. S11-S20. Koeslag, P. T. Saunders, J. A. Wessels
  • J. Endocrinology 154,
  • 1997
Highly Influential
4 Excerpts

Biological homeostasis of the global environment

  • A. J. Watson, J. E. Lovelock
  • Tellus
  • 1983
1 Excerpt

Cusp catastrophe in pituitary thyrotropin secretion

  • F. J. Seif
  • nat. Acad. Sci. USA
  • 1979
1 Excerpt

Similar Papers

Loading similar papers…