Intasome architecture and chromatin density modulate retroviral integration into nucleosome

@inproceedings{Benleulmi2015IntasomeAA,
  title={Intasome architecture and chromatin density modulate retroviral integration into nucleosome},
  author={Mohamed Salah Benleulmi and Julien Matysiak and Daniel R Henr{\'i}quez and C{\'e}dric Vaillant and Paul Lesbats and Christina Calmels and Monica Naughtin and Oscar De Leon and Anna Marie Ann Skalka and Marc Ruff and Marc Lavigne and Marie-Line Andr{\'e}ola and Vincent Parissi},
  booktitle={Retrovirology},
  year={2015}
}
BackgroundRetroviral integration depends on the interaction between intasomes, host chromatin and cellular targeting cofactors as LEDGF/p75 or BET proteins. Previous studies indicated that the retroviral integrase, by itself, may play a role in the local integration site selection within nucleosomal target DNA. We focused our study on this local association by analyzing the intrinsic properties of various retroviral intasomes to functionally accommodate different chromatin structures in the… CONTINUE READING
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