Intake of vitamin D and risk of type 1 diabetes: a birth-cohort study

@article{Hyppnen2001IntakeOV,
  title={Intake of vitamin D and risk of type 1 diabetes: a birth-cohort study},
  author={Elina Hypp{\"o}nen and Esa Läärä and Antti R Reunanen and Marjo-Riitta J{\"a}rvelin and Suvi M. Virtanen},
  journal={The Lancet},
  year={2001},
  volume={358},
  pages={1500-1503}
}
BACKGROUND Dietary vitamin D supplementation is associated with reduced risk of type 1 diabetes in animals. Our aim was to ascertain whether or not vitamin D supplementation or deficiency in infancy could affect development of type 1 diabetes. METHODS A birth-cohort study was done, in which all pregnant women (n=12055) in Oulu and Lapland, northern Finland, who were due to give birth in 1966 were enrolled. Data was collected in the first year of life about frequency and dose of vitamin D… Expand
Lack of Association Between Maternal or Neonatal Vitamin D Status and Risk of Childhood Type 1 Diabetes: A Scandinavian Case-Cohort Study
TLDR
It is demonstrated that normal variation in maternal or neonatal 25(OH)D is unlikely to have a clinically important effect on risk of childhood T1D. Expand
High-dose vitamin D supplements are not associated with linear growth in a large Finnish cohort.
TLDR
Contrary to proposed evidence suggesting that vitamin D has a negative influence on growth rate at a dosage of ~2000 IU/d, supplementation at this level in the Northern Finland Birth Cohort was not associated with reduced height at any age studied. Expand
Maternal intake of vitamin D during pregnancy and risk of advanced beta cell autoimmunity and type 1 diabetes in offspring
TLDR
Maternal intake of vitamin D either from food or supplements during pregnancy is not associated with advanced beta cell autoimmunity/type 1 diabetes or with type 1 diabetes alone in Finnish offspring carrying increased genetic susceptibility to type 1abetes. Expand
Vitamin D at the onset of type 1 diabetes in Italian children
TLDR
Children at onset of T1DM have lower vitamin D serum levels than those with other diseases and the hypothesis that low vitamin D levels may increase the odds for developing diabetes is tested. Expand
High prevalence of vitamin D deficiency in type 1 diabetes mellitus and healthy children
TLDR
Vitamin D intake was very poor in children and it shows that supplementing infants with vitamin D might be a safe and effective strategy for reducing the risk of T1DM. Expand
Assessing the population impact of low rates of vitamin D supplementation on type 1 diabetes using a new statistical method
TLDR
Calculations show that for the population of 729,674 babies born in England and Wales in 2012, 374 cases of type 1 diabetes could be prevented over 18 years if all were supplemented with vitamin D, which could lead to savings in excess of £62 million for the cohort. Expand
Maternal Serum Levels of 25-Hydroxy-Vitamin D During Pregnancy and Risk of Type 1 Diabetes in the Offspring
TLDR
Findings provide support for the initiation of a randomized intervention trial to prevent type 1 diabetes in children by enhancing maternal 25-OH D status during pregnancy. Expand
Vitamin D supplementation in early childhood and risk of type 1 diabetes: a systematic review and meta-analysis
TLDR
Vitamin D supplementation in early childhood may offer protection against the development of type 1 diabetes, according to a systematic review and meta-analysis based on observational studies. Expand
Neonatal vitamin D status is not associated with later risk of type 1 diabetes: results from two large Danish population-based studies
TLDR
Two large-scale national studies showed that 25(OH)D3 levels around the time of birth were not associated with later type 1 diabetes risk, and higher levels of 25( OH)D 3 during pregnancy, acquired by higher doses of supplementation than are recommended today in most countries, could protect the offspring against type 1 Diabetes. Expand
Vitamin D Deficiency and Glycemic Status in Children and Adolescents with Type 1 Diabetes Mellitus
TLDR
Children with T1DM show a generalized 25OHD deficiency that impact on metabolic status and glycemic homeostasis and Vitamin D supplementation improves glycemic control and should be considered as an additional therapy. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 27 REFERENCES
Vitamin D supplement in early childhood and risk for Type I (insulin-dependent) diabetes mellitus
TLDR
This large multicentre trial covering many different European settings consistently showed a protective effect of vitamin D supplementation in infancy, indicating that activated vitamin D might contribute to immune modulation and thereby protect or arrest an ongoing immune process initiated in susceptible people by early environmental exposures. Expand
Early introduction of dairy products associated with increased risk of IDDM in Finnish children. The Childhood in Diabetes in Finland Study Group.
TLDR
This is the first observational study to show that early introduction of dairy products is independently associated with an increased risk of IDDM. Expand
Cow’s milk consumption, disease‐associated autoantibodies and Type 1 diabetes mellitus: a follow‐up study in siblings of diabetic children
TLDR
It is suggested that high consumption of cow’s milk during childhood may be associated both with seroconversion to positivity for diabetes‐associated autoantibodies and progression to clinical Type 1 DM among siblings of children with diabetes. Expand
Changes of vitamin D3 serum concentrations at the onset of immune-mediated type 1 (insulin-dependent) diabetes mellitus.
TLDR
It was demonstrated that the decrease of 1,25-(OH)2D3 was primarily present during summer and due to a loss of the seasonal rhythm of this hormone observed in healthy controls, yielding a similar loss of seasonal variation also of this vitamin D3 metabolite in Type 1 (insulin-dependent) diabetic patients. Expand
Vitamin D supplementation, 25-hydroxyvitamin D concentrations, and safety.
  • R. Vieth
  • Medicine
  • The American journal of clinical nutrition
  • 1999
TLDR
The assembled data from many vitamin D supplementation studies reveal a curve for vitamin D dose versus serum 25-hydroxyvitamin D [25(OH)D] response that is surprisingly flat up to 250 microg (10000 IU) vitamin D/d. Expand
The onset age of type 1 diabetes in Finnish children has become younger. The Finnish Childhood Diabetes Registry Group.
TLDR
The greatest increase in the incidence of type 1 diabetes mainly occurred in children aged < 5 years, and the incidence in young boys has been increasing since the mid-1960s, whereas in young girls, the significant increase began later, around the late-1970s. Expand
Diet of Finnish Children in Relation to the Family's Socio-Economic Status
TLDR
If these childhood dietary differences remain in adulthood, it is possible that the present disparity between socio-economic groups in mortality from coronary heart disease will not disappear. Expand
PREVALENCE AND TEN‐YEAR (1970‐1979) INCIDENCE OF INSULIN‐DEPENDENT DIABETES MELLITUS IN CHILDREN AND ADOLESCENTS IN FINLAND
TLDR
The prevalence of diabetes mellitus increased clearly during the observation period, and the incidence tended to increase especially during the last years, possibly the highest in the world. Expand
Worldwide increase in incidence of Type I diabetes – the analysis of the data on published incidence trends
TLDR
The incidence of Type I diabetes is increasing worldwide both in low and high incidence populations, and by the year 2010 the incidence will be 50 per 100 000 a year in Finland and also in many other populations it will exceed 30 per 100000 a year. Expand
Influence of social background on psychomotor development in the first year of life and its correlation with later intellectual capacity: a prospective cohort study.
TLDR
The fast learners during their first year of life were superior to the others in their educational capacity at the age of 14 years and the prognosis in this respect was independent of social class. Expand
...
1
2
3
...