Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies

  title={Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies},
  author={Ahmad Jayedi and Mahdieh Sadat Zargar},
  journal={Critical Reviews in Food Science and Nutrition},
  pages={2697 - 2707}
  • A. JayediM. Zargar
  • Published 15 November 2018
  • Medicine
  • Critical Reviews in Food Science and Nutrition
Abstract The objective of this study was to quantify the association of B-vitamins intake with the future risk of coronary heart disease (CHD). A systematic search was performed with the use of PubMed and Scopus from inception to April 30, 2018. Prospective cohort studies evaluating the association of intake of folate, vitamin B6, and vitamin B12 with risk of CHD in the general population were included. A random-effects meta-analysis was performed. Eleven prospective cohort studies (total n… 

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B vitamins are associated with cardiovascular mortality in the general population and intake of folate and B6 (but not B12) was significantly associated with cerebrovascular mortality.

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The present work in CHD-free middle-aged men is the first prospective cohort study to observe a significant inverse association between quantitatively assessed moderate-to-high folate intakes and incidence of acute coronary events in men.

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High dietary intakes of folate and vitamin B6 were associated with reduced risk of mortality from stroke, coronary heart disease, and heart failure among Japanese.

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A greater benefit for CVD was observed among participants with lower plasma folate levels and without preexisting CVD and in studies with larger decreases in homocysteine levels, while folic acid supplementation had no significant effect on risk of coronary heart disease.

Prospective cohort studies of dietary vitamin B6 intake and risk of cause-specific mortality.

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An increased intake of dietary folate equivalents was observed to be associated with decreased risk of myocardial infarction in a German study population, pointing towards the importance of folate intake with respect to primary prevention of my Cardiac Infarction.