Intake of trans fatty acids and risk of coronary heart disease among women

@article{Willett1993IntakeOT,
  title={Intake of trans fatty acids and risk of coronary heart disease among women},
  author={Walter C. Willett and Meir J. Stampfer and JoAnn E. Manson and Graham A. Colditz and F. E. Speizer and Bernard A Rosner and Charles H. Hennekens and Laura A. Sampson},
  journal={The Lancet},
  year={1993},
  volume={341},
  pages={581-585}
}

Tables from this paper

A Prospective Study of Trans Fatty Acids in Erythrocytes and Risk of Coronary Heart Disease
TLDR
After adjustment for age, smoking status, and other dietary and lifestyle cardiovascular risk factors, higher total trans fatty acid content in erythrocytes was associated with an elevated risk of CHD, providing further evidence that high trans fat consumption remains a significant risk factor for CHD after adjustment for covariates.
Dietary fat intake and the risk of coronary heart disease in women.
TLDR
It is suggested that replacing saturated and trans unsaturated fats with unhydrogenated monounsaturated and polyunsaturated fats is more effective in preventing coronary heart disease in women than reducing overall fat intake.
Does dietary trans fatty acid intake relate to the prevalence of coronary heart disease in Scotland?
TLDR
Dietary total and commercially-derived trans fatty acids failed to influence the odds of coronary heart disease for men, even though a significant increase in the ratio of low density plus very low density lipoprotein to high densitylipoprotein-cholesterol occurred with trans fatty acid intake.
Intake of fatty acids and risk of coronary heart disease in a cohort of Finnish men. The Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study.
TLDR
A significant positive association was observed between the intake of trans-fatty acids and the risk of coronary death in a cohort of 21,930 smoking men aged 50-69 years who were initially free of diagnosed cardiovascular disease.
DIETARY ANTIOXIDANT VITAMINS AND DEATH FROM CORONARY HEART DISEASE IN POSTMENOPAUSAL WOMEN
TLDR
The results suggest that in postmenopausal women the intake of vitamin E from food is inversely associated with the risk of death from coronary heart disease and that such women can lower their risk without using vitamin supplements.
DIETARY FAT INTAKE AND THE RISK OF CORONARY HEART DISEASE IN WOMEN DIETARY FAT INTAKE AND THE RISK OF CORONARY HEART DISEASE IN WOMEN
TLDR
It is suggested that replacing saturated and trans unsaturated fats with unhydrogenated monounsaturated and polyunsaturated fats is more effective in preventing coronary heart disease in women than reducing overall fat intake.
Consumption of trans fats and estimated effects on coronary heart disease in Iran
TLDR
Intake of TFAs is high in Iranian homes and contributes to a sizeable proportion of CHD events, and replacement of partially hydrogenated oils with unhydrogenated oils would likely produce substantial reductions in CHD incidence.
Quantitative effects on cardiovascular risk factors and coronary heart disease risk of replacing partially hydrogenated vegetable oils with other fats and oils
TLDR
Effects on CHD risk of removing PHVO from a person's diet vary depending on the TFA content of the PHVO and the fatty acid composition of the replacement fat or oil, with direct implications for reformulation of individual food products.
...
...

References

SHOWING 1-10 OF 29 REFERENCES
Effect of dietary cis and trans fatty acids on serum lipoprotein[a] levels in humans.
TLDR
Examination of the effect of dietary fatty acid composition on serum Lp[a] levels in three strictly controlled experiments with healthy normocholesterolemic men and women found that saturated fatty acids are a strong risk factor for coronary heart disease.
Effect of dietary trans fatty acids on high-density and low-density lipoprotein cholesterol levels in healthy subjects.
TLDR
The effect of trans fatty acids on the serum lipoprotein profile is at least as unfavorable as that of the cholesterol-raising saturated fatty acids, because they not only raise LDL cholesterol levels but also lower HDL cholesterol levels.
Relation of meat, fat, and fiber intake to the risk of colon cancer in a prospective study among women.
TLDR
These prospective data provide evidence for the hypothesis that a high intake of animal fat increases the risk of colon cancer, and they support existing recommendations to substitute fish and chicken for meats high in fat.
Fatty acid composition of subcutaneous adipose tissue and diet in postmenopausal US women.
TLDR
Investigation of the distributions of fatty acids in subcutaneous-adipose-tissue aspirates and their relation to intake as assessed by a semiquantitative food-frequency questionnaire suggest that intakes of polyunsaturated fatty acids, including n-3 fatty acid, and trans fatty acids are reflected in the adipose tissue but that intake of saturated and monounsaturated fatty acid are not.
Trends in individual consumption of dietary fat in the United States, 1920-1984.
TLDR
A search of published individual assessments of food intake since 1920 indicated a fall in US fat intake, which preceded the decline in heart disease mortality, which differ markedly from food supply trends.
Nutrition imbalance and angiotoxins as dietary risk factors in coronary heart disease.
  • F. Kummerow
  • Medicine
    The American journal of clinical nutrition
  • 1979
TLDR
Since population groups that consume less vitamin D-supplemented foods, less deep fat fried cholesterol-containing foods, and less hydrogenated fats have a lower incidence of coronary heart disease than Americans, it seems judicious for food processors to reduce these previously unconsidered risk factors to a minimum.
Plasma lipoprotein lipid and Lp[a] changes with substitution of elaidic acid for oleic acid in the diet.
TLDR
In 27 mildly hypercholesterolemic men, total and LDL cholesterol were significantly lower during the 3-week oleic acid-rich diet, and were similar during the other three diets, which led to significant elevations in the level of Lp compared to all the other test diets.
Concentration of 18:1 and 16:1 transunsaturated fatty acids in the adipose body tissue of decedents dying of ischaemic heart disease compared with controls: analysis by gas liquid chromatography.
TLDR
It is concluded that the cases consumed on average a higher proportion of those hydrogenated fats rich in 16:1Trans and 18:1 trans acids and a lower proportion of ruminant fat than did the controls.
Postmenopausal estrogen therapy and cardiovascular disease.
TLDR
After adjustment for age and other risk factors, the overall relative risk of major coronary disease in women currently in the Nurses' Health Study is low, and the effect of estrogens on stroke is unclear.
...
...