Intake of grapefruit juice alters the metabolic pattern of cyclosporin A in renal transplant recipients.


OBJECTIVE The aim of the present study was to investigate the effect of grapefruit juice on the pharmacokinetics of cyclosporin A (CsA), as Sandimmun Neoral, and its main metabolites, M1, M9 and M4N, in renal transplant recipients. METHODS Ten renal transplant recipients, on CsA-based immunosuppressive therapy, were included in this open, randomized… (More)