Intake of folate and related nutrients in relation to risk of epithelial ovarian cancer.

@article{Tworoger2006IntakeOF,
  title={Intake of folate and related nutrients in relation to risk of epithelial ovarian cancer.},
  author={Shelley S. Tworoger and Jonathan L. Hecht and Edward L. Giovannucci and Susan E Hankinson},
  journal={American journal of epidemiology},
  year={2006},
  volume={163 12},
  pages={
          1101-11
        }
}
Assessments of the relation between folate intake and ovarian cancer risk have been limited and inconsistent. Therefore, the authors prospectively examined the association of dietary and supplemental intakes of folate, methionine, and vitamin B(6) with ovarian cancer risk among 80,254 Nurses' Health Study participants. Beginning in 1976, women completed biennial questionnaires assessing ovarian cancer risk factors; starting in 1980, food frequency questionnaires were administered every 2-4… 
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Dietary betaine and choline intake are not associated with risk of epithelial ovarian cancer
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There were no associations between total choline, betaine, as well as choline plus betaine intake and ovarian cancer risk and these data provide little evidence for a role of these nutrients in ovarian cancer etiology.
Relationship between dietary and supplemental intake of folate, methionine, vitamin B6 and folate receptor α expression in ovarian tumors
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The hypothesis that the relationship between factors involved in one‐carbon metabolism and ovarian cancer risk differs by FRα status of the tumor is not supported.
Intake of vitamins A, C, and E and folate and the risk of ovarian cancer in a pooled analysis of 10 cohort studies
TLDR
It is suggested that consumption of vitamins A, C, and E and folate during adulthood does not play a major role in ovarian cancer risk, and dietary and total intakes of each vitamin were not significantly associated with ovarian cancerrisk.
Dietary intake of selected B vitamins in relation to risk of major cancers in women
TLDR
This large study provides little support for an association of dietary intake thiamin, riboflavin, niacin, folate, or methionine with five major cancers in women and explores possible effect modification by combinations of nutrients on cancer risk.
The effect of folate intake on ovarian cancer risk
TLDR
It is demonstrated that folate intake had no significant association on the risk of ovarian cancer while some other related factors were not investigated due to the limited information provided in each included study.
Folate, vitamin B6, vitamin B12, methionine and alcohol intake in relation to ovarian cancer risk
TLDR
Overall, it is observed that there is no significant association between folate and ovarian cancer risk, and one‐carbon metabolism related nutrients, especially vitamin B6 and methionine, may lower ovarian cancerrisk.
Dairy food and nutrient intake in different life periods in relation to risk of ovarian cancer
TLDR
Findings do not support the hypothesis that higher lactose intake increases EOC risk, and the inverse association with endometrioid tumors deserves further study.
Dietary Intake and Ovarian Cancer Risk: A Systematic Review
TLDR
It is suggested that no specific dietary factors are consistently associated with ovarian cancer risk and studies of ample sample size, varied exposure, and which can better control for dietary measurement error are needed to fully define dietary recommendations for ovarian cancer prevention.
Association between dietary intake and risk of ovarian cancer: a systematic review and meta-analysis
TLDR
Recommendations to green leafy vegetables, allium vegetables, fiber, flavonoids and green tea intake for ovarian cancer prevention are supported, and acrylamide, nitrate, water disinfectants and polychlorinated biphenyls were significantly associated with an increased risk of ovarian cancer.
Surrogates of Long-Term Vitamin D Exposure and Ovarian Cancer Risk in Two Prospective Cohort Studies
TLDR
This study evaluated ultraviolet (UV)-B radiation, vitamin D intake, and predicted plasma 25-hydroxyvitamin D levels as long-term surrogates of vitamin D exposure within the Nurses’ Health Study (NHS) and NHSII and does not strongly support a protective role for vitamin D in ovarian cancer risk.
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References

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It is suggested that alcohol consumption is inversely related to postmenopausal ovarian cancer, and that the association of folate with ovarian cancer may vary by the amount of alcohol consumed.
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TLDR
A high dietary folate intake may play a role in reducing the risk of ovarian cancer, especially among women who consume alcohol.
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TLDR
Higher plasma levels of folate and possibly vitamin B(6) may reduce the risk of developing breast cancer and achieving adequate circulating levels of Folate may be particularly important for women at higher risk ofdeveloping breast cancer because of higher alcohol consumption.
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TLDR
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TLDR
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TLDR
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TLDR
Higher total folate intake was associated with a decreased risk of incident hypertension, particularly in younger women, and among women who did not take folic acid-containing supplements, dietary folate Intake was not significantly associated with risk of hypertension.
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