Intact pituitary function is decisive for the catabolic response to TNF-α: studies of protein, glucose and fatty acid metabolism in hypopituitary and healthy subjects.

@article{Bach2015IntactPF,
  title={Intact pituitary function is decisive for the catabolic response to TNF-α: studies of protein, glucose and fatty acid metabolism in hypopituitary and healthy subjects.},
  author={Ermina Bach and Andreas Buch M{\o}ller and Jens Otto Lunde J{\o}rgensen and Mikkel Holm Vendelbo and Niels Jessen and Jonas F Olesen and Steen B{\o}nlykke Pedersen and Thomas S Nielsen and Niels M{\o}ller},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2015},
  volume={100 2},
  pages={
          578-86
        }
}
CONTEXT TNF-α generates inflammatory responses and insulin resistance, lipolysis, and protein breakdown. It is unclear whether these changes depend on intact hypothalamo-pituitary stress hormone responses to trigger the release of cortisol and growth hormone. OBJECTIVE To define differential effects of TNF-α on glucose, protein, and lipid metabolism in hypopituitary patients (without intact hypothalamo-pituitary axis) and healthy controls. DESIGN Randomized, placebo controlled, single… CONTINUE READING
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