Intact carrageenan-induced thermal hyperalgesia in mice lacking inducible nitric oxide synthase.

@article{Tao2003IntactCT,
  title={Intact carrageenan-induced thermal hyperalgesia in mice lacking inducible nitric oxide synthase.},
  author={Feng Tao and Ya-Xiong Tao and Peizhong Mao and Chao Zhao and D Li and W-J Liaw and Srinivasa N Raja and Roger A. Johns},
  journal={Neuroscience},
  year={2003},
  volume={120 3},
  pages={847-54}
}
To date, the exact role of inducible nitric oxide synthase (iNOS) in inflammatory pain remains controversial. In the present study, we combined a pharmacological strategy (using a selective iNOS inhibitor) with a genomic strategy (using mice lacking the iNOS gene) to address the function of iNOS in the central mechanism of carrageenan-induced persistent inflammatory pain. In the wild type mice, intrathecal administration of L-N(6)-(1-iminoethyl)-lysine, a selective iNOS inhibitor, significantly… CONTINUE READING
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