Intact cannabinoid CB1 receptors in the Alzheimer's disease cortex.

  title={Intact cannabinoid CB1 receptors in the Alzheimer's disease cortex.},
  author={Jasinda H-Q Lee and Grzegorz Agacinski and James Williams and G. K. Wilcock and Margaret M. Esiri and Paul T Francis and Peter T-H Wong and Christopher Chen and Mitchell Kim Peng Lai},
  journal={Neurochemistry international},
  volume={57 8},
The cannabinoid CB1 receptor has gained much attention as a potential pharmacotherapeutic target in various neurodegenerative diseases including Alzheimer's disease (AD). However, the relation of CB1 receptors to cognitive function in AD is at present unclear. In this study, postmortem brain tissues from a cohort of prospectively assessed, neuropathologically confirmed AD patients and aged controls were used to measure CB1 receptors by immunoblotting, and a subset of subjects also had [(3)H… CONTINUE READING


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