Intact TRL 9 and type I interferon signaling pathways are required to augment HSV-1 induced corneal CXCL9 and CXCL10

@article{Wuest2006IntactT9,
  title={Intact TRL 9 and type I interferon signaling pathways are required to augment HSV-1 induced corneal CXCL9 and CXCL10},
  author={Todd Wuest and Bobbie Ann Austin and Satoshi Uematsu and Manoj Thapa and Daniel J J Carr},
  journal={Journal of Neuroimmunology},
  year={2006},
  volume={179},
  pages={46-52}
}
Herpes simplex virus type 1 ocular infection elicits a potent inflammatory response including the production of the chemokines, CXCL9 and CXCL10, in mice. Since HSV-1 nucleic acid is recognized by pattern receptors including Toll-like receptor (TLR) 9, we tested the hypothesis that TLR9 is necessary for the early augmentation of CXCL10 following HSV-1 infection. Similar to wild type controls, TLR9 deficient mice constitutively expressed CXCL10 in the cornea. Following infection or stimulation… CONTINUE READING

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