Intact Mre11/Rad50/Nbs1 complex predicts good response to radiotherapy in early breast cancer.

@article{Sderlund2007IntactMC,
  title={Intact Mre11/Rad50/Nbs1 complex predicts good response to radiotherapy in early breast cancer.},
  author={Karin S{\"o}derlund and Olle St{\aa}l and Lambert Skoog and Lars Erik Rutqvist and B O Nordenskj{\"o}ld and Marie Stenmark Askmalm},
  journal={International journal of radiation oncology, biology, physics},
  year={2007},
  volume={68 1},
  pages={50-8}
}
PURPOSE To investigate the expression and predictive role of the Mre11/Rad50/Nbs1 (MRN) complex and the ataxia-telangiectasia mutated protein (ATM) for the outcome of radiotherapy in breast cancer patients. METHODS AND MATERIALS The protein expression of ATM and the DNA repair proteins in the MRN complex were investigated using immunohistochemistry in tumors from 224 women with early breast cancer, who were randomized to receive postoperative radiotherapy or adjuvant chemotherapy. RESULTS… CONTINUE READING

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