Intact Alzheimer amyloid precursor protein (APP) is present in platelet membranes and is encoded by platelet mRNA.

@article{Gardella1990IntactAA,
  title={Intact Alzheimer amyloid precursor protein (APP) is present in platelet membranes and is encoded by platelet mRNA.},
  author={J E Gardella and Jorge Ghiso and Gaetano Gorgone and D E Marratta and Allen P. Kaplan and Blas Frangione and Peter D. Gorevic},
  journal={Biochemical and biophysical research communications},
  year={1990},
  volume={173 3},
  pages={1292-8}
}
Using antibodies directed against N-terminal and C-terminal epitopes we have immunologically detected APP species in the membrane and saline-soluble fractions of unstimulated platelets, and in the conditioned medium of thrombin-stimulated platelets. These studies demonstrate an intact 140 kD membrane-associated form of APP that is released on degranulation. Evidence that platelets synthesize at least one form of APP (APP751) was obtained by enzymatic amplification of specific mRNA using… CONTINUE READING

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