Intégration du VIH-1 : Contrôle et régulation de l'interaction fonctionnelle entre l’intégrase et la chromatine

@inproceedings{Matysiak2016IntgrationDV,
  title={Int{\'e}gration du VIH-1 : Contr{\^o}le et r{\'e}gulation de l'interaction fonctionnelle entre l’int{\'e}grase et la chromatine},
  author={Julien Matysiak},
  year={2016}
}
HIV-1 integrase (IN) is a key enzyme of the viral cycle that catalyzes the stable insertion of viral DNA into the genome of the infected cell. IN also participates in many stages of the viral cycle such as reverse transcription or viral maturation. Thus, an understanding of the mechanisms regulating the integration of HIV-1 is a major challenge, particularly in the context of therapeutic approaches. Indeed, studies show that these mechanisms are finely regulated in the cell by viral and… CONTINUE READING

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