Insulinotropin PACAP potentiates insulin-stimulated glucose uptake in 3T3 L1 cells.

@article{Nakata1999InsulinotropinPP,
  title={Insulinotropin PACAP potentiates insulin-stimulated glucose uptake in 3T3 L1 cells.},
  author={Masanori Nakata and Seiji Shioda and Yoshitomo Oka and Ikuro Maruyama and Toshihiko Yada},
  journal={Peptides},
  year={1999},
  volume={20 8},
  pages={943-8}
}
Pituitary adenylate cyclase-activating polypeptide (PACAP) is localized in pancreatic nerve fibers and islets and potently augments glucose-induced insulin secretion. The present study explored a possible extra-pancreatic action of PACAP. The specific PACAP receptor (PAC1 receptor) was expressed in the rat fat tissue and 3T3-LI adipocytes. PACAP-38 (10 nM) significantly enhanced insulin-induced 2-deoxyglucose uptake by 3T3-L1 adipocytes. Insulin-stimulated phosphatidylinositol 3-kinase activity… CONTINUE READING
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