Insulinoma with hypoglycemia and normal immunoreactive insulin but with an insulin-like activity restricted to the portal vein

@article{Mirouze1978InsulinomaWH,
  title={Insulinoma with hypoglycemia and normal immunoreactive insulin but with an insulin-like activity restricted to the portal vein},
  author={Jacques Mirouze and Georges Marchal and Andr{\'e} Orsetti and Claude Jaffiol and Louis Monnier and Pierre Baldet and Michel Piperno and Bernard H{\'e}don},
  journal={Acta diabetologia latina},
  year={1978},
  volume={15},
  pages={205-211}
}
In a 46-year old Caucasian woman, the authors report a B-cell adenoma with plasma immuno-reactive insulin (IRI) ranging from 10 to 32 µU/ml, despite severe spontaneous hypoglycemia. In a peroperative sample withdrawn from the portal vein, normal IRI (40 µU/ml) in the presence of high insulin-like activity (290 µU/ml) was observed by using a biological assay… CONTINUE READING