Insulinlike growth factor I regulation of growth hormone gene transcription in primary rat pituitary cells.

Abstract

We have previously shown that insulinlike growth factor I (IGF-I) inhibits growth hormone (GH) secretion and messenger RNA (mRNA) levels in pituitary cells. The effects of IGF-I on new GH mRNA synthesis rates in primary monolayer rat pituitary cells were therefore examined by nuclear runoff transcription assays. IGF-I (1.3 nM) treatment for 1 h inhibited GH… (More)

4 Figures and Tables

Topics

  • Presentations referencing similar topics