Insulin therapy for type 2 diabetes: rescue, augmentation, and replacement of beta-cell function.

@article{Mayfield2004InsulinTF,
  title={Insulin therapy for type 2 diabetes: rescue, augmentation, and replacement of beta-cell function.},
  author={Jennifer A. Mayfield and Russell Donald White},
  journal={American family physician},
  year={2004},
  volume={70 3},
  pages={
          489-500
        }
}
Type 2 diabetes is characterized by progressive beta-cell failure. Indications for exogenous insulin therapy in patients with this condition include acute illness or surgery, pregnancy, glucose toxicity, contraindications to or failure to achieve goals with oral antidiabetic medications, and a need for flexible therapy. Augmentation therapy with basal insulin is useful if some beta-cell function remains. Replacement therapy with basal-bolus insulin is required for beta-cell exhaustion. Rescue… CONTINUE READING

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