Insulin structure and stability.

  title={Insulin structure and stability.},
  author={Jens Brange and L Langkjoer},
  journal={Pharmaceutical biotechnology},
Insulin is composed of 51 amino acids in two peptide chains (A and B) linked by two disulfide bonds. The three-dimensional structure of the insulin molecule (insulin monomer), essentially the same in solution and in solid phase, exists in two main conformations. These differ in the extent of helix in the B chain which is governed by the presence of phenol or its derivatives. In acid and neutral solutions, in concentrations relevant for pharmaceutical formulation, the insulin monomer assembles… CONTINUE READING


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