Insulin stimulates the tyrosine phosphorylation of caveolin

  title={Insulin stimulates the tyrosine phosphorylation of caveolin},
  author={Cynthia Corley Mastick and Matthew J. Brady and Alan R. Saltiel},
  journal={The Journal of Cell Biology},
  pages={1523 - 1531}
The specialized plasma membrane structures termed caveolae and the caveolar-coat protein caveolin are highly expressed in insulin-sensitive cells such as adipocytes and muscle. Stimulation of 3T3-L1 adipocytes with insulin significantly increased the tyrosine phosphorylation of caveolin and a 29-kD caveolin-associated protein in caveolin-enriched Triton-insoluble complexes. Maximal phosphorylation occurred within 5 min, and the levels of phosphorylation remained elevated for at least 30 min… CONTINUE READING
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