Insulin stimulates osteoblast proliferation and differentiation through ERK and PI3K in MG-63 cells.

@article{Yang2010InsulinSO,
  title={Insulin stimulates osteoblast proliferation and differentiation through ERK and PI3K in MG-63 cells.},
  author={Jianhong Yang and Xiaolin Zhang and Weiwei Wang and Jing Liu},
  journal={Cell biochemistry and function},
  year={2010},
  volume={28 4},
  pages={
          334-41
        }
}
Insulin has been proposed to be an anabolic agent in bone, but the mechanisms underlying insulin effects on osteoblast differentiation are still not clear. To explore the mechanisms of action of insulin on osteoblast growth and differentiation, human osteoblastic cell line-MG-63 was used and stimulated by insulin in the presence or absence of ERK inhibitor PD98059, PI3-K inhibitor LY294002, or inhibitor PD98059 + LY294002. The results showed that insulin positively regulated the expression of… CONTINUE READING

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