Insulin stimulates mitochondrial protein synthesis and respiration in isolated perfused rat heart.

@article{McKee1990InsulinSM,
  title={Insulin stimulates mitochondrial protein synthesis and respiration in isolated perfused rat heart.},
  author={Edward E. McKee and Bonnie L Grier},
  journal={The American journal of physiology},
  year={1990},
  volume={259 3 Pt 1},
  pages={E413-21}
}
The rates of synthesis of mitochondrial proteins by both the cytoplasmic and mitochondrial protein synthetic systems, as well as parameters of respiration, were measured and compared in mitochondria isolated from fresh, control perfused, and insulin-perfused rat hearts. The respiratory control ratio (RCR) in mitochondria from fresh hearts was 8.1 +/- 0.4 and decreased to 6.0 +/- 0.2 (P less than 0.001 vs. fresh) in mitochondria from control perfused hearts and to 6.7 +/- 0.2 (P less than 0.005… CONTINUE READING

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