Insulin stimulates both leptin secretion and production by rat white adipose tissue.

@article{Barr1997InsulinSB,
  title={Insulin stimulates both leptin secretion and production by rat white adipose tissue.},
  author={Valarie A Barr and Daniela Malide and Mary Jane Zarnowski and Simeon I Taylor and Samuel W. Cushman},
  journal={Endocrinology},
  year={1997},
  volume={138 10},
  pages={4463-72}
}
Leptin, the peptide encoded by the obese gene, is secreted by adipose cells and plays a role in regulating food intake, energy expenditure, and adiposity. Because earlier studies suggested that insulin increases the expression of leptin, we investigated the effect of insulin on leptin secretion by adipose tissue. Epididymal fat pads were incubated in vitro in the presence or absence of insulin over a 4-h time course. Insulin increased leptin secretion by about 80% at all time points studied… CONTINUE READING
Highly Influential
This paper has highly influenced 11 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 116 extracted citations

Regulation of the leptin content of obese human adipose tissue.

American journal of physiology. Endocrinology and metabolism • 2001
View 4 Excerpts
Highly Influenced

Integration of hormonal and nutrient signals that regulate leptin synthesis and secretion.

American journal of physiology. Endocrinology and metabolism • 2009
View 5 Excerpts
Highly Influenced

Expression of ob gene coding the production of the hormone leptin in hepatocytes of liver with steatosis.

Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia • 2001
View 6 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…