Insulin-stimulated phosphorylation of lipin mediated by the mammalian target of rapamycin

@article{Huffman2002InsulinstimulatedPO,
  title={Insulin-stimulated phosphorylation of lipin mediated by the mammalian target of rapamycin},
  author={Todd A Huffman and I. Mothe-Satney and J. Lawrence},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2002},
  volume={99},
  pages={1047 - 1052}
}
The phosphorylation of a previously uncharacterized protein of apparent Mr ≈ 140,000 was found to be increased when rat adipocytes were incubated with insulin. The sequences of peptides generated by digesting the protein with trypsin matched perfectly with sequences in mouse lipin. Lipin is the product of the gene that is mutated in fatty liver dystrophy (fld) mice [Peterfy, M., Phan, J., Xu, P. & Reue, K (2001) Nat. Genet. 27, 121–124], which exhibit several phenotypic abnormalities including… Expand
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