Insulin-stimulated glycogen synthesis in cultured hepatoma cells: differential effects of inhibitors of insulin signaling molecules.

@article{Sung1998InsulinstimulatedGS,
  title={Insulin-stimulated glycogen synthesis in cultured hepatoma cells: differential effects of inhibitors of insulin signaling molecules.},
  author={Chin K Sung and Woo Sik Choi and Pierluigi Scalia},
  journal={Journal of receptor and signal transduction research},
  year={1998},
  volume={18 4-6},
  pages={243-63}
}
In rat HTC hepatoma cells overexpressing human insulin receptors, insulin stimulated glycogen synthesis by 55-70%. To study postreceptor signaling events leading to insulin-stimulated glycogen synthesis in these cells, we have employed pathway-specific chemical inhibitors such as LY294002, rapamycin and PD98059 to inhibit phosphatidylinositol-3-kinase (PI3K… CONTINUE READING