Insulin-stimulated glucose uptake involves the transition of glucose transporters to a caveolae-rich fraction within the plasma membrane: implications for type II diabetes.

@article{Gustavsson1996InsulinstimulatedGU,
  title={Insulin-stimulated glucose uptake involves the transition of glucose transporters to a caveolae-rich fraction within the plasma membrane: implications for type II diabetes.},
  author={Johanna Gustavsson and Santiago Parpal and Peter Str{\aa}lfors},
  journal={Molecular medicine},
  year={1996},
  volume={2 3},
  pages={
          367-72
        }
}
BACKGROUND Adipose and muscle tissues express an insulin-sensitive glucose transporter (GLUT4). This transporter has been shown to translocate from intracellular stores to the plasma membrane following insulin stimulation. The molecular mechanisms signalling this event and the details of the translocation pathway remain unknown. In type II diabetes, the cellular transport of glucose in response to insulin is impaired, partly explaining why blood-glucose levels in patients are not lowered by… CONTINUE READING

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