Insulin-stimulated GLUT4 translocation in adipocytes is dependent upon cortical actin remodeling.

@article{Kanzaki2001InsulinstimulatedGT,
  title={Insulin-stimulated GLUT4 translocation in adipocytes is dependent upon cortical actin remodeling.},
  author={Makoto Kanzaki and Jeffrey E. Pessin},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 45},
  pages={42436-44}
}
Rhodamine-labeled phalloidin staining of morphologically differentiated 3T3L1 adipocytes demonstrated that F-actin predominantly exists juxtaposed to and lining the inner face of the plasma membrane (cortical actin) with a smaller amount of stress fiber and/or ruffling actin confined to the cell bottom in contact with the substratum. The extent of cortical actin disruption with various doses of either latrunculin B or Clostridium difficile toxin B (a Rho family small GTP-binding protein toxin… CONTINUE READING
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