Insulin stabilizes microvascular endothelial barrier function via phosphatidylinositol 3-kinase/Akt-mediated Rac1 activation.

@article{Guenduez2010InsulinSM,
  title={Insulin stabilizes microvascular endothelial barrier function via phosphatidylinositol 3-kinase/Akt-mediated Rac1 activation.},
  author={Dursun Guenduez and Johannes Thom and Imran Hussain and Diego Guarin Lopez and Frauke Viola H{\"a}rtel and Ali Erdoğan and Mathias Grebe and Daniel Sedding and Hans Michael Piper and Harald Tillmanns and Thomas Noll and Muhammad Aslam},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2010},
  volume={30 6},
  pages={1237-45}
}
OBJECTIVE Insulin is a key regulator of metabolism, but it also confers protective effects on the cardiovascular system. Here, we analyze the mechanism by which insulin stabilizes endothelial barrier function. METHODS AND RESULTS Insulin reduced basal and antagonized tumor necrosis factor-alpha-induced macromolecule permeability of rat coronary microvascular endothelial monolayers. It also abolished reperfusion-induced vascular leakage in isolated-perfused rat hearts. Insulin induced… CONTINUE READING