Insulin signals control the competence of the Drosophila female germline stem cell niche to respond to Notch ligands.

@article{Hsu2011InsulinSC,
  title={Insulin signals control the competence of the Drosophila female germline stem cell niche to respond to Notch ligands.},
  author={Hwei-Jan Hsu and Daniela Drummond-Barbosa},
  journal={Developmental biology},
  year={2011},
  volume={350 2},
  pages={290-300}
}
Adult stem cells reside in specialized microenvironments, or niches, that are essential for their function in vivo. Stem cells are physically attached to the niche, which provides secreted factors that promote their self-renewal and proliferation. Despite intense research on the role of the niche in regulating stem cell function, much less is known about how the niche itself is controlled. We previously showed that insulin signals directly stimulate germline stem cell (GSC) division and… CONTINUE READING