Insulin signalling regulates remating in female Drosophila

  title={Insulin signalling regulates remating in female Drosophila},
  author={Stuart Wigby and Cathy Slack and Sebastian Gr{\"o}nke and P Mart{\'i}nez and Federico C. F. Calboli and Tracey Chapman and Linda Partridge},
  booktitle={Proceedings. Biological sciences},
Mating rate is a major determinant of female lifespan and fitness, and is predicted to optimize at an intermediate level, beyond which superfluous matings are costly. In female Drosophila melanogaster, nutrition is a key regulator of mating rate but the underlying mechanism is unknown. The evolutionarily conserved insulin/insulin-like growth factor-like signalling (IIS) pathway is responsive to nutrition, and regulates development, metabolism, stress resistance, fecundity and lifespan. Here we… CONTINUE READING
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