Insulin signalling downstream of protein kinase B is potentiated by 5′AMP-activated protein kinase in rat hearts in vivo

@article{Longnus2005InsulinSD,
  title={Insulin signalling downstream of protein kinase B is potentiated by 5′AMP-activated protein kinase in rat hearts in vivo},
  author={Sarah L Longnus and Coralie S{\'e}galen and Jean François Giudicelli and Mini P. Sajan and Robert V Farese and Emmanuel Van Obberghen},
  journal={Diabetologia},
  year={2005},
  volume={48},
  pages={2591-2601}
}
5′AMP-activated protein kinase (AMPK) and insulin stimulate glucose transport in heart and muscle. AMPK acts in an additive manner with insulin to increase glucose uptake, thereby suggesting that AMPK activation may be a useful strategy for ameliorating glucose uptake, especially in cases of insulin resistance. In order to characterise interactions between the insulin- and AMPK-signalling pathways, we investigated the effects of AMPK activation on insulin signalling in the rat heart in vivo… CONTINUE READING
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