Insulin signalling: metabolic pathways and mechanisms for specificity.

  title={Insulin signalling: metabolic pathways and mechanisms for specificity.},
  author={Fredrik H Nystrom and Michael J. Quon},
  journal={Cellular signalling},
  volume={11 8},
Biological actions of insulin are mediated by the insulin receptor, a member of a large family of receptor tyrosine kinases (RTK). Signal transduction by the insulin receptor follows a paradigm for RTK signalling. Many intracellular signalling molecules contain multiple modular domains that mediate protein-protein interactions and participate in the formation of signalling complexes. Phosphorylation cascades are also a prominent feature of RTK signalling. Distal pathways are difficult to… CONTINUE READING