Insulin signaling to the glomerular podocyte is critical for normal kidney function.

  title={Insulin signaling to the glomerular podocyte is critical for normal kidney function.},
  author={Gavin I. Welsh and Lorna J Hale and Vera Eremina and Marie Jeansson and Yoshiro Maezawa and Rachel Lennon and Deborah A Pons and Rachel J Owen and Simon C. Satchell and Mervyn J. Miles and Christopher James Caunt and Craig Alexander McArdle and Hermann J. Pavenst{\"a}dt and Jeremy Tavare and Andrew M. Herzenberg and C Ronald Kahn and Peter William Mathieson and Susan E Quaggin and Moin Saleem and Richard J. M. Coward},
  journal={Cell metabolism},
  volume={12 4},
Diabetic nephropathy (DN) is the leading cause of renal failure in the world. It is characterized by albuminuria and abnormal glomerular function and is considered a hyperglycemic "microvascular" complication of diabetes, implying a primary defect in the endothelium. However, we have previously shown that human podocytes have robust responses to insulin. To determine whether insulin signaling in podocytes affects glomerular function in vivo, we generated mice with specific deletion of the… CONTINUE READING
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