Insulin signaling through insulin receptor substrate 1 and 2 in normal liver development.

@article{Khamzina2003InsulinST,
  title={Insulin signaling through insulin receptor substrate 1 and 2 in normal liver development.},
  author={L. Khamzina and P. Gruppuso and J. Wands},
  journal={Gastroenterology},
  year={2003},
  volume={125 2},
  pages={
          572-85
        }
}
  • L. Khamzina, P. Gruppuso, J. Wands
  • Published 2003
  • Biology, Medicine
  • Gastroenterology
  • BACKGROUND & AIMS The insulin growth factor signal transduction pathway is an important regulator of adult hepatocyte proliferation. The purpose of this study was to determine the roles of the insulin receptor substrate (IRS-1 and IRS-2)-mediated growth cascades in rapidly growing fetal rat liver. METHODS We determined the expression and tyrosyl phosphorylation of the insulin receptor beta subunit (IRbeta), IRS-1 and IRS-2, the binding of phosphatidylinositol 3-kinase (PI3K), and activation… CONTINUE READING
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