Insulin signaling is acutely required for long-term memory in Drosophila

@article{Chambers2015InsulinSI,
  title={Insulin signaling is acutely required for long-term memory in Drosophila},
  author={Daniel B. Chambers and Alaura Androschuk and Cory S. Rosenfelt and Steven Langer and M. Harding and F. Bolduc},
  journal={Frontiers in Neural Circuits},
  year={2015},
  volume={9}
}
  • Daniel B. Chambers, Alaura Androschuk, +3 authors F. Bolduc
  • Published 2015
  • Biology, Medicine
  • Frontiers in Neural Circuits
  • Memory formation has been shown recently to be dependent on energy status in Drosophila. A well-established energy sensor is the insulin signaling (InS) pathway. Previous studies in various animal models including human have revealed the role of insulin levels in short-term memory but its role in long-term memory remains less clear. We therefore investigated genetically the spatial and temporal role of InS using the olfactory learning and long-term memory model in Drosophila. We found that InS… CONTINUE READING
    22 Citations

    Figures and Topics from this paper.

    Age-Related Changes in Insulin-like Signaling Lead to Intermediate-Term Memory Impairment in Drosophila.
    • 8
    Signaling Pathways for Long-Term Memory Formation in the Cricket
    • 4
    • PDF
    Function of insulin in snail brain in associative learning
    • 19

    References

    SHOWING 1-10 OF 45 REFERENCES
    Insulin Signaling Plays a Dual Role in Caenorhabditis elegans Memory Acquisition and Memory Retrieval
    • 59
    • PDF
    Mutations in the Drosophila insulin receptor substrate, CHICO, impair olfactory associative learning
    • 21
    Specific requirement of NMDA receptors for long-term memory consolidation in Drosophila ellipsoid body
    • 161
    • PDF
    Genetic dissection of consolidated memory in Drosophila
    • 782
    Insulin receptor signaling in the development of neuronal structure and function
    • 149
    • PDF
    To Favor Survival Under Food Shortage, the Brain Disables Costly Memory
    • 89
    • PDF
    Induction of a dominant negative CREB transgene specifically blocks long-term memory in Drosophila
    • 936
    Genetic analysis of insulin signaling in Drosophila
    • R. Garofalo
    • Medicine, Biology
    • Trends in Endocrinology & Metabolism
    • 2002
    • 295
    • PDF
    Excess protein synthesis in Drosophila Fragile X mutants impairs long-term memory
    • 185
    • PDF
    Regulation of hunger-driven behaviors by neural ribosomal S6 kinase in Drosophila.
    • Q. Wu, Y. Zhang, J. Xu, P. Shen
    • Biology, Medicine
    • Proceedings of the National Academy of Sciences of the United States of America
    • 2005
    • 229
    • PDF