Insulin signaling in the pancreatic beta-cell.

  title={Insulin signaling in the pancreatic beta-cell.},
  author={Ingo B. Leibiger and Barbara Leibiger and P. -O. Berggren},
  journal={Annual review of nutrition},
The appropriate function of insulin-producing pancreatic beta-cells is crucial for the regulation of glucose homeostasis, and its impairment leads to diabetes mellitus, the most common metabolic disorder in man. In addition to glucose, the major nutrient factor, inputs from the nervous system, humoral components, and cell-cell communication within the islet of Langerhans act together to guarantee the release of appropriate amounts of insulin in response to changes in blood glucose levels. Data… CONTINUE READING

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