Insulin signaling in the nervous system regulates ethanol intoxication in Drosophila melanogaster

Abstract

The insulin signaling pathway regulates multiple physiological processes, including energy metabolism, organismal growth, aging and reproduction. Here we show that genetic manipulations in Drosophila melanogaster that impair the function of insulin-producing cells or of the insulin-receptor signaling pathway in the nervous system lead to increased… (More)
DOI: 10.1038/nn1363

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